Arsenal and Manchester United go into Tuesday's round of UEFA Champions League matches confident of securing their places in the knockout stages unlike Celtic who face a stern test to keep their hopes alive.
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Both Premier League sides top their groups and victories for the pair will see them into the last 16 with a game to spare
All eyes will be on Emirates Stadium as Cesc Fabregas prepares to lead out the Gunners against Dynamo Kiev.
The young Spaniard takes the captain's armband for the first time, succeeding William Gallas who looks likely to return to the starting line-up.
Should Fabregas inspire Arsenal to victory, they will qualify from Group G, rendering next month's visit to Porto meaningless.
Troubles
The Portuguese face Fenerbahçe knowing a win in Istanbul will take them through to the latter stages with a game to spare unless Dynamo Kiev make the most of Arsenal's current troubles and spring a surprise at Emirates.
Anything less than a victory for Fener will leave them clinging to the hope of a Uefa Cup berth.
Fenerbahçe have managed only three goals in their four group games, yet coach Luis Aragonés points to their domestic form as a source for optimism with the Turks notching 24 in the league so far this term.
In Group E, Manchester United are in Spain to face Villarreal knowing that a draw will see both sides through to the last 16.
The holders travelled without goalkeeper Edwin van der Sar, Gary Neville and Dimitar Berbatov.
Tomasz Kuszczak replaces the Dutchman in goal while Sir Alex Ferguson is likely to include Cristiano Ronaldo in spite of the injury he picked up against Aston Villa at the weekend.
Villarreal coach Manuel Pellegrini is adamant his side - including former United striker Giuseppe Rossi - will not play out a tame draw and wants to put on a show at El Madrigal to put the Yellow Submarines in pole position to win the group.
A victory for either side is exactly what Celtic need if they are to stand any chance of making it to the knockout stages.
But to stand any hope of moving into the last 16, they must beat Aalborg in Denmark and end a run which has seen them fail to win in 19 away games and lose their last ten.
The two sides drew 0-0 when they met in Glasgow earlier in the campaign and defeat for either this time would see them finish bottom of the group. A win, on the other hand, would guarantee third place and a spot in the Uefa Cup, while also keeping alive faint hopes of making the last 16.
Fiorentina start their Group F game with Lyon knowing only a victory will keep their Champions League hopes alive.
Recovered
With the Italians five points behind group leaders Lyon and Bayern Munich, anything less than a first win of the campaign would leave the Viola unable to do better than third place and a Uefa Cup slot.
Lyon, for their part, need just a point at the Stadio Artemio Franchi to assure a sixth consecutive qualification for the knockout phase.
A point for Bayern at home to struggling Steaua Bucharest will almost certainly be enough to see Jurgen Klinsmann's side through to the last 16.
Philipp Lahm has recovered from an ankle injury and is likely to return at left-back against the Romanians who have just a single point from their first four matches and no chance of making the last 16.
In Group H, Zenit St Petersburg welcome a Juventus side already assured of a place in the knockout stages courtesy of their double over Real Madrid.
The Bianconeri travel to Russia weakened by the absence of seven first-team players including Gianluigi Buffon, David Trezeguet and Cristiano Zanetti.
Dick Advocaat's St Petersburg need victory over the Italians to maintain their push for a last 16 place but will be without injured midfielder Lee Ho and the suspended Sébastian Puygrenier, though Belgian defender Nicolas Lombaerts should be fit.
Both Real Madrid and BATE Borisov can still make it through to the latter stages as they prepare to face each other in Group H's other encounter.
The Belarussian champions have to win against the Spanish giants while Real must also come away with victory unless results go their way in St Petersburg.